Tulathromycin 217500-96-4 Antibiotic Antifungal
Intlawulo:T/T, L/C
Imvelaphi yeMveliso:eTshayina
Indawo yokuthumela ngenqanawa:Beijing/Shanghai/Hangzhou
Umthamo wemveliso:400kg/ngenyanga
Umyalelo(MOQ):25kg
Ixesha lokukhokhela:Iintsuku zokusebenza ezi-3
Imeko yokugcina:Igcinwe kwindawo epholileyo, eyomileyo, ubushushu begumbi.
Ipakethe imathiriyeli:igubu
Ubungakanani bepakethi:25kg/igubu
Ulwazi ngokhuseleko:Ayizompahla eziyingozi
Intshayelelo
I-Tulathromycin, yi-arhente ye-antibacterial-spectrum ebanzi kunye nomsebenzi we-antibacterial ngokuchasene ne-gram-positive kunye ne-Gram-negative bacteria.Ichaphazeleka ngakumbi kwiintsholongwane zezifo zokuphefumla kwiinkomo kunye neehagu, ezinje ngeActinobacillus pleuropneumoniae, Pasteurella haemolyticus, Pasteurella haemorrhagica, histophilus sleep (Haemophilus sleep), Mycoplasma pneumoniae, Haemophilus parasuis, Bordetella bronchiseptica, njl.
Iimpawu ze-pharmacokinetic ze-Tulathromycin kukuba emva kokulawulwa kwedosi enye, ifunxwa ngokukhawuleza kwindawo yokutofa, ukuxinwa kwegazi okusebenzayo kugcinwa ixesha elide, ukupheliswa kucotha, umthamo obonakalayo wokusabalalisa mkhulu, i-bioavailability iphezulu, kwaye Ugxininiso kwi-peripheral tissue iphezulu kune-plasma.Ukuhanjiswa kwezicubu ezibanzi kunye nokunyanzeliswa kakuhle kweeseli ziimpawu ezibalulekileyo ze-Tulathromycin metabolism.Ukuqokelelana kwiiseli zokuzivikela komzimba kukwayinto ebalulekileyo yeTulathromycin.
I-Tulathromycin inqanda iprotheyini ye-bacterial synthesis ngokuthintela inkqubo yokudlulisa i-peptide yebhaktheriya.Ngenxa yeziphene ezibalulekileyo ze-erythromycin, abantu bafuna elinye iyeza endaweni ye-erythromycin ngokukhawuleza.I-Tulathromycin luhlobo olutsha lwe-macrolide semi synthetic antibiotics yezilwanyana.Ineenzuzo ezininzi, ezifana nedosi ephantsi, ulawulo lwexesha elinye, intsalela ephantsi, isilwanyana esithile njalo njalo.Ayinayo nje inzuzo yamachiza e-macrolide, kodwa ikwanesiqingatha sobomi obude obuphezulu kunezinye i-macrolide antibiotics.Ngokusekwe kwinzuzo yokugcina ugxininiso lonyango olusebenzayo emzimbeni ixesha elide, inokufezekisa i-bacteriostasis engcono kunye nokuvala inzala.
Emva kokusetyenziswa kwekliniki ngokubanzi, i-tulathromycin inefuthe elicacileyo lonyango kwizifo zokuphefumla zeenkomo kunye neehagu.Enkosi ngomsebenzi ogqwesileyo we-antibacterial we-Tulathromycin njengedosi encinci usebenzisa, isiqingatha sobomi obude kunye nolawulo lwexesha elinye, lunokusetyenziswa ngokubanzi.
I-Tulathromycin yomelele kune-macrolides esetyenziswa ngokubanzi kwimarike ngoku, njenge-tylosin, i-tilmicosin kunye ne-florfenicol.Enezicelo ezinkulu ezinokubakho.
Ingqalelo kufuneka ihlawulwe ukuba i-Tulathromycin ikhuselekile, ngaphandle kwe-carcinogenicity, i-teratogenicity kunye ne-genotoxicity.Ayizukubangela ukuguquka kwemfuza, kodwa inokuvelisa i-cardiotoxicity.Kufuneka ulandele iingcebiso zogqirha wezilwanyana.
Inkcazo (kwiMgangatho weNdlu)
| Into | Inkcazo |
| Imbonakalo | Umgubo omhlophe okanye phantse omhlophe |
| Ukunyibilika | Inyibilika ngokukhululekileyo kwi-methanol, i-acetone, kunye ne-methyl acetate, inyibilika kwi-ethanol. |
| Ukujikeleza okuthe ngqo | -22 ° ukuya -26 ° |
| Ukuchongwa | I-HPLC: ixesha lokugcinwa kwencopho enkulu kwichromatogram yolungiselelo lovavanyo luhambelana naleyo ikwichromatogram yolungiselelo lwestrandard olufunyenwe njengoko kuchaziwe kuvavanyo. I-IR: I-spectrum ye-IR iyahambelana ne-CRS |
| Amanzi | ≤2.5% |
| Intsalela ekutshisweni | ≤0.10% |
| Iintsimbi ezinzima | ≤20ppm |
| Into enxulumeneyo | Ukungcola ngokupheleleyo ≤6.0% Ukungcola komntu ≤3.0% |
| I-endotoxin yebhaktheriya | <2 EU |
| Uvavanyo (into engenamanzi) | 95%-103% |
| Isinyibilikisi esishiyekileyo | N-Heptane≤5000ppm IDichloromethane ≤600ppm |
| Isivavanyi | Umxholo kaC41H79N3O12: 95% -103% (Kwinto eAnydrous) |
