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Imveliso

Rivaroxaban 366789-02-8 Inkqubo yegazi ikhusela i-Antithrombosis Umfanekiso obonakalayo
  • I-Rivaroxaban 366789-02-8 Inkqubo yegazi ikhusela i-Antithrombosis

I-Rivaroxaban 366789-02-8 Inkqubo yegazi ikhusela i-Antithrombosis

Inkcazelo emfutshane:

Izithethantonye:5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

Inombolo yeCAS:366789-02-8

Umgangatho:EP

Ifomula yemolekyuli:I-C19H18ClN3O5S

Ubunzima beFomula:435.88


Iinkcukacha zeMveliso

Iithegi zeMveliso

Intlawulo:T/T, L/C
Imvelaphi yeMveliso:eTshayina
Indawo yokuthumela ngenqanawa:Beijing/Shanghai/Hangzhou
Umthamo wemveliso:200kg/ngenyanga
Umyalelo(MOQ):25kg
Ixesha lokukhokhela:Iintsuku zokusebenza ezi-3
Imeko yokugcina:Igcinwe kwindawo epholileyo, eyomileyo, ubushushu begumbi.
Ipakethe imathiriyeli:igubu
Ubungakanani bepakethi:25kg/igubu
Ulwazi ngokhuseleko:Ayizompahla eziyingozi

Rivaroxaban

Intshayelelo

I-Rivaroxaban, iyeza le-anticoagulant (igazi elincinci).Isetyenziswa kubantu abadala abane-nonvalvular fibrillation ye-atrial (ngaphandle kwe-fibrillation ye-atrial ngenxa yesifo senhliziyo se-rheumatic valvular, kunye ne-atrial fibrillation emva kokutshintshwa kwevalve yentliziyo) ukunciphisa umngcipheko we-stroke kunye ne-systemic embolism.
I-Rivaroxaban, isetyenziselwa ukunyanga nokukhusela ama-blood clots.
I-Rivaroxaban, isetyenziselwa izigulane ezikhulileyo ezithatha i-hip ekhethiweyo okanye utyando lokutshintshwa kwamadolo ukukhusela i-venous thrombosis.

Inkcazo (EP)

Into

Inkcazo

Imbonakalo

Umgubo omhlophe okanye omthubi

Ukunyibilika

Ngokuqhelekileyo ayinyibiliki emanzini, i-soluble ngokukhululekileyo kwi-DMSO, ayinyibiliki kwi-ethanol ene-anhydrous kunye ne-heptanes.

Ukuchongwa

IR: ISpectrum kufuneka ihambelane ne-WS
 

I-HPLC-RT yesampulu phantsi kovavanyo lokucoceka kwe-enantiometric kufuneka ihambelane naleyo ye-WS.
Amanzi ≤0.5%

Uthuthu lwesulphate

 ≤0.1%

Ilahleko ekomisweni

 ≤0.5%
Iintsimbi ezinzima ≤20ppm

Umenzi

 Ukungcola A: ≤0.4%

Isinyibilikisi esishiyekileyo

 I-Ethanol: ≤5000ppm

I-Ethyl acetate: ≤5000ppm

I-acetone: ≤5000ppm

N, N-Dimethylformamide: ≤880ppm

I-Methylene chloride: ≤600ppm

I-Benzene: ≤2ppm

Into enxulumeneyo

 Ukungcola B: ≤0.10%

Ukungcola D: ≤0.10%

Ukungcola E: ≤0.10%

Ukungcola F: ≤0.10%

Ukungcola G: ≤0.10%

Ukungcola H: ≤0.10%

Ukungcola I: ≤0.10%

Ukungcola J: ≤0.10%

I-RVB-4-NJSH: ≤0.10%

RVB-ZA: ≤0.10%

I-RVB-BAM: ≤0.10%

I-RVB-ZC: ≤0.10%

I-RVB-HBY: ≤75ppm

Nakuphi na okunye ukungcola okungaziwayo: ≤0.10%

Ukungcola ngokupheleleyo: ≤0.3%

Ukuhanjiswa kobungakanani besuntswana

 D10:/

D50:/

D90:/
Isivavanyi

(into engenamanzi)

 98.0-102.0
  • Ngaphambili:
  • Okulandelayo:

    • iimveliso ezinxulumene