Alprostadil, ekwabizwa ngokuba yi-PGE1, luhlobo lwemathiriyeli ekrwada yamayeza, esetyenziswa kakhulu kumayeza nakwiindawo ezinxulumeneyo.Ifumaneka njengenaliti okanye ngendlela ye-suppositories kunye ne-topical creams yonyango.Njengenye yezinto eziphambili ezisetyenziselwa ukuveliswa kwe-prostaglandin E1 (PGE1) derivatives, i-alprostadil idlala indima ebalulekileyo ekunciphiseni i-arteries kunye nokuphucula ukuhamba kwegazi kwiindawo ezithile zezicubu kwizigulane ezine-erectile dysfunction (ED).Izifundo zeklinikhi ziye zagqiba ukuba i-alprostadil iphucula ngokufanelekileyo ukulungiswa ngokukhupha i-nitric oxide, evuselela iiseli ze-muscle ezigudileyo ezibandakanyekayo kwinkqubo yokumisa.Ukongezelela, kuye kwaboniswa ukuba kusebenza ngokukhawuleza kakhulu kuneyeza zendabuko zomlomo xa zilawulwa nge-intracavernously okanye intraurethrally.
Ngokubhekiselele kwisenzo se-pharmacological, i-alprostadil ikakhulu isebenza njenge-agonist ye-prostaglandin receptor, kunye ne-prostaglandin receptors zifumaneka kuwo wonke umzimba womntu.Esi senzo sivelisa iziphumo ezifana ne-vasodilation, okubangelwa ukunyuka kwegazi lendawo;i-bronchoconstriction ukunciphisa iimpawu ze-asthma;kunokwenzeka ukunciphisa i-apoptosis kwizifo ezinxulumene nomhlaza;ukunciphisa ukuvuvukala, kunye nokunye.Iimpawu zayo ezinomsebenzi omninzi zenza ukuba ibe sisithako esifanelekileyo kwiinkqubo ezahlukeneyo zokuphuhliswa kwamachiza, ukusuka kunyango lwe-ED ukuya kunyango lomhlaza kunye nokunye, kuxhomekeke kwingxaki ethile imveliso yokugqibela kufuneka ijongane nayo.
Ukongeza ekulungiselelweni kweenjongo zonyango zezifo ezahlukeneyo ngokusebenzisa iindlela zokulawula ezifana nenaliti okanye iifom ze-suppository;xa kuthelekiswa neemveliso ezifanayo kwiimarike, i-PGE1 iphinda ibonise iziphumo ezibi kakhulu, ezibandakanya intloko ebuhlungu emva kokusetyenziswa, kude kube buthathaka ngokupheleleyo emva kweeyure ezimbalwa;nangona ziyenzeka ngamanye amaxesha, zidla ngokungaqhelekanga ukuba zenziwe ngokuchanekileyo kwiidosi ezimiselweyo, ziqala ngezikhokelo zokusetyenziswa kwexesha elide ezinikezelwe ngugqirha ochazayo.Ngaphezu koko, ngokweemvavanyo zamva nje zenzululwazi ezenziwa kumazwe ngamazwe, ngokubanzi, ixesha lokuqalisa ngokupheleleyo kwesenzo liyahluka ukusuka kwimizuzu eyi-15 kuphela ukuya kutsho kubude bemizuzu engama-30, kodwa ngokwendalo iziphumo zixhomekeke kakhulu kwisigulana ngasinye kubume bemeko.
Ngokubanzi, i-PGE1 ibonise isiphumo esiluncedo esimangalisayo, ngakumbi kumadoda aneziphazamiso ezingalunganga zokuziphatha ngokwesondo kunye neengxaki zesimo somzimba Unyango olumiselweyo ngokwesiko aluphumelelanga ngenxa yokunqongophala kwamandla asebenzayo kunye nobunzima bemiba ekhoyo kufuneka iqwalaselwe ngokwaneleyo, ngaphandle kokukhathazeka malunga nempilo enzulu. iingxaki, ukwenza ukuba ibe lukhetho olukhuselekileyo nolusebenzayo.
Ixesha lokuposa: Mar-06-2023