I-Alprostadil 745-65-3 iHormone kunye ne-endocrine
Intlawulo:T/T, L/C
Imvelaphi yeMveliso:eTshayina
Indawo yokuthumela ngenqanawa:Beijing/Shanghai/Hangzhou
Umthamo wemveliso:1kg/ngenyanga
Umyalelo(MOQ): 1g
Ixesha lokukhokhela:Iintsuku zokusebenza ezi-3
Imeko yokugcina:kunye nengxowa yomkhenkce yokuthutha, -20 ℃ yokugcina ixesha elide
Ipakethe imathiriyeli:ibhotile, ibhotile
Ubungakanani bepakethi:1g/ibhodlela, 5/ibhotile, 10g/ibhotile, 50g/ibhotile, 500g/ibhotile
Ulwazi ngokhuseleko:UN 2811 6.1/PG 3
Intshayelelo
I-Alprostadil, ebizwa ngokuba yiProstaglandin E1 okanye i-PEG1.Ifumaneka ngokubanzi kumzimba wezinto eziphilayo ezisebenzayo, njengenye yeentsapho ze-prostaglandin, yinto eyaziwayo engapheliyo ye-physiologically esebenzayo.
Ingasetyenziselwa ngokuthe ngqo kwi-vascular smooth muscle, ukusabalalisa imithwalo yegazi kunye nokwandisa ukuhamba kwegazi, okunokuphucula i-microcirculation perfusion.Inokuthintela ukuhlanganiswa kweplatelet kunye nokuveliswa kwe-thromboxane A2, kunye nokuthintela i-atherosclerosis, i-lipid plaque kunye ne-immune complex formation.
Ikwanayo neziphumo ezilandelayo: ukwandiswa kwemithambo yegazi emincinci yegazi kunye nemithambo ye-coronary, ukunciphisa i-peripheral vascular resistance kunye noxinzelelo lwegazi.Ukukhusela inwebu yeplatelet enokumelana ne-thrombosis.Ukukhusela i-ischemic myocardium, enokunciphisa ubungakanani be-myocardial infarct.Isetyenziselwa ukunyanga ukusilela kwentliziyo ngokunjalo.Inomsebenzi we-diuretic kunye ne-renal-protect, isiseko ekwandiseni imithambo yegazi yezintso ukwenzela ukwandisa ukuhamba kwegazi kwizintso.Ngale ndlela, inokususa i-nitrogen engeyona iprotheni, kunye nokulawula ukulingana kwe-sodium kunye namanzi.
Ukusetyenziswa kweklinikhi kubanzi.Njengeengxaki zesifo seswekile, isifo sentliziyo kunye nokungaphumeleli kwentliziyo.Kwakhona kusetyenziswa kwimeko efana nesifo sentliziyo sokuzalwa esintsonkothileyo ngenxa yoxinzelelo lwegazi lwepulmonary, i-cerebral infarction kunye nesifo esingapheliyo se-arterial occlusive disease.Kwezinye iimeko ezifana nokungeva ngesiquphe, ukuvaleka kwemithambo ye-retinal, i-viral hepatitis okanye i-gastritis engapheliyo, nayo inomsebenzi.Inokusetyenziswa eklinikhi kwezinye izifo ezifana nesilonda se-duodenal, ukungasebenzi kakuhle kwezintso kunye ne-pancreatitis.Kusetyenziswa kufakelo lwamalungu.Isetyenziselwa ezinye izifo ezifana ne-erectile dysfunction, induction labor and postpartum hemorrhage, i-femoral head necrosis, i-lumbar disc herniation, i-postherpetic neuralgia kunye ne-asthma ye-bronchial.
Kufuneka ilumke isetyenziswe kwizigulana ezinesifo esifana nokusilela kwentliziyo, iglaucoma, isilonda se-peptic okanye inyumoniya yangaphakathi.Ngomphumo ocaphukisayo kwi-vein, uya kubonisa iimpawu zokuvuvukala ezifana nokubomvu, ukuvuvukala, ukushisa kunye neentlungu, ezinokubangela i-phlebitis.Kufuneka iyeke ukusetyenziselwa ukhuseleko xa imeko isenzeka.
Inkcazo (USP43)
| Into | Inkcazo |
| Imbonakalo | Umgubo wekristale omhlophe okanye otyheli kancinane |
| Ukuchongwa | IR |
| Intsalela ekutshisweni | ≤0.5% |
| Umda wechromium | ≤0.002% |
| Umda werhodium | ≤0.002% |
| Izinto ezinxulumeneyo | Prostaglandin A1 ≤1.5% |
| Prostaglandin B1 ≤0.1% | |
| Nakuphi na ukungcola kwe-prostaglandin yangaphandle eluting phambi kwe-prostaglandin A1 ≤0.9% | |
| Ukungcola ngexesha lokugcinwa kwe-0.6, ngokumalunga ne-prostaglandin A1 ≤0.9% | |
| Isimbuku sokungcola ngamaxesha okugcinwa okuhambelanayo 2.0 kunye ne-2.3 ≤0.6% | |
| Nakuphi na okunye ukungcola kwe-prostaglandin yangaphandle eluting emva kwe-prostaglandin A1 ≤0.9% | |
| Ubumdaka bubonke ≤2.0% | |
| Ukuzimisela kwamanzi | ≤0.5% |
| Izinyibilikisi ezishiyekileyo | I-Ethanol ≤5000ppm |
| I-acetone ≤5000ppm | |
| IDichloromethane ≤600ppm | |
| N-Hexane ≤290ppm | |
| N-Heptane ≤5000ppm | |
| I-Ethyl acetate ≤5000ppm | |
| Uvavanyo (kwisiseko se-anhydrous) | 95.0%~105.0% |
