Iindaba

Ipeptide yobhedu ikwabizwa ngegamaGHK-cuyinkimbinkimbi eyenziwe yindibaniselwano yetripptide-1kunye neyoni yobhedu.Idatha yophando ibonisa ukuba ubhedu kumzimba wezilwanyana ludlala indima ebalulekileyo ngeendlela ezahlukeneyo, ngokukodwa ngempembelelo yobhedu kwii-enzymes ze-antioxidant.Zininzi ii-enzymes ezibalulekileyo emzimbeni womntu kunye nolusu olufuna ii-ion zobhedu.Ezi enzymes zidlala indima ekubunjweni kwezicubu ezidibeneyo, i-anti-oxidation kunye nokuphefumla kweeseli.I-Copper nayo idlala indima yokubonisa, enokuchaphazela ukuziphatha kunye ne-metabolism yeeseli.Xa iCopper peptide inyibilika emanzini, ibonisa umbala ozuba wasebukhosini okwabizwa ngokuba yiBlue Copper peptide kwindawo yoshishino.

Uphando lubonisa ukuba iCopper peptide ineenzuzo ezininzi zokhathalelo lwesikhumba, enesicelo esikhulu esinokubakho kushishino lwezithambiso.

1. Indima yepeptide yobhedu ekulungisweni kwesikhumba

Uphando lubonisa i-peptide yobhedu imodareyitha i-metalloproteinase ezahlukeneyo kwinkqubo yokwakhiwa kwakhona kwesikhumba seempuku.Umsebenzi we-enzyme ukhuthaza ukubola kweeprotheni ze-matrix ze-extracellular, ezinokuthi zilungelelanise ukubola kweeprotheni ze-matrix ezingaphandle (iiprotheni ze-ECM) kunye nokukhusela umonakalo ogqithiseleyo wesikhumba.Ipeptide yobhedu yonyusa iproteoglycan engundoqo.Umsebenzi wale proteoglycan kukuthintela ukubunjwa kwezibazi kunye nokunciphisa izinga lokuguqula ukukhula kwe-beta (TGF beta), eyandisa izibazi ngokulawula ukuhlanganiswa kwe-collagen fibrils.

2. Ivuselela i-collagen synthesis

Iimvavanyo ezininzi ziqinisekisile ukuba i-tripeptide-1 ivuselela ukuhlanganiswa kwe-collagen, i-glycosaminoglycan ekhethiweyo kunye neprotheni encinci ye-glycan deproteinization.Ukongeza, inokulawula ukuhlanganiswa kwee-metalloproteinases ezinxulumeneyo.Ezinye zezi enzymes ziyakukhawulezisa ukubola kweeproteni ze-matrix ezingaphandle, ngelixa ezinye zinokuthintela umsebenzi weprotease.Oku kubonisa ukuba i-peptide yobhedu inokulawula inqanaba leprotheyini eluswini.

3. Anti inflammatory kunye ne-antioxidant

Kwafunyaniswa ukuba i-peptide yethusi inqanda ukuvuvukala ngokunciphisa amanqanaba e-cytokines avuthayo afana ne-TGF-beta kunye ne-TNF-a kwisigaba esinzima.I-Tripeptide-1 ikwanciphisa umonakalo we-oxidative ngokulawula inqanaba lentsimbi kunye nokucima iimveliso ezinetyhefu ze-fatty acid lipid peroxidation.

4. Khuthaza ukuphiliswa kwenxeba

Izifundo ezininzi zezilwanyana ziqinisekisile ukuba i-peptide yobhedu eluhlaza inamandla okuphilisa amanxeba.Kuvavanyo lomvundla, i-peptide yobhedu eluhlaza inokukhawulezisa ukuphiliswa kwesilonda, ikhuthaze i-angiogenesis, kwaye yandise umxholo we-antioxidant enzymes egazini.

5. Buyisela umsebenzi weeseli ezonakalisiweyo

I-Fibroblasts ziiseli eziphambili zokuphulukisa amanxeba kunye nokuvuselelwa kwezicubu.Abahlanganisi kuphela amacandelo ahlukeneyo e-matrix engaphandle, kodwa bavelisa inani elikhulu lezinto zokukhula.Uphononongo ngo-2005 lubonise ukuba i-tripeptide-1 inokubuyisela ukusebenza kwe-fibroblasts ene-irradiated.

Ipeptide yobhedu luhlobo lwepolypeptide enokuchasana nokuguga kunye nokulungisa izinto.Ayinakukhuthaza kuphela ukuveliswa kohlobo lwe-I, i-IV kunye ne-VII ye-collagen, kodwa iphinde ikhuthaze umsebenzi we-collagen synthesis cells fibroblast, eyona nto ibalaseleyo kakhulu yokulwa nokuguga.

Ngokumalunga nokulungiswa, i-peptide yethusi inokukhusela i-fibroblasts evuselelwe yi-UV, iphucule umsebenzi wayo, inciphise ukukhuselwa kwe-MMP-1, ijongane ngokufanelekileyo nezinto ezivuthayo eziveliswa ngovelwano, zigcine umsebenzi wokuthintela ulusu wonakaliswe ngenxa yempembelelo yangaphandle, kwaye ine-anti egqwesileyo. I-allergic kunye namandla athomalalisayo.I-peptide yobhedu idibanisa ukuguga kunye nokulungiswa, okunqabile kakhulu kwizinto ezikhoyo zokulwa nokuguga kunye nokulungiswa.