Amphotericin B 1397-89-3 Antibiotic
Intlawulo:T/T, L/C
Imvelaphi yeMveliso:eTshayina
Indawo yokuthumela ngenqanawa:Beijing/Shanghai/Hangzhou
Umthamo wemveliso:100kg/ngenyanga
Umyalelo(MOQ):25kg
Ixesha lokukhokhela:Iintsuku zokusebenza ezi-3
Imeko yokugcina:kunye nengxowa yomkhenkce yokuthutha.Gcina kwi-2-8℃ ixesha elide.
Ipakethe imathiriyeli:igubu
Ubungakanani bepakethi:25kg/igubu
Ulwazi ngokhuseleko:Ayizompahla eziyingozi
Intshayelelo
I-Amphotericin B, inokubizwa ngokuba yiFungizone okanye i-Ambisome, isibulala-zintsholongwane se-polyene esilwa nokungunda okwahlulwa kulwimi lwenkcubeko ye-Streptomycesnodosus.Ibekwe yodwa ngamalungu amabini ane-A kunye no-B, kodwa inxalenye engu-A ayisebenzi kangako kwi-antifungal engasetyenziswayo, ngoko ke abantu basebenzisa inxalenye engu-B kuphela ebizwa ngokuba yi-Amphotericin B.
Liyeza le-antifungal elisetyenziselwa usulelo olukhulu lomngundo kunye ne-leishmaniasis.Inokusetyenziswa ezimbini ezahlukeneyo ngomlomo kunye nesitofu.
I-Amphotericin B lukhetho lokuqala losulelo lomngundo olunzulu ngenxa yobubanzi bayo bokulwa nokungunda.Inomsebenzi wokuthintela ukungunda okufana ne-cryptococcus, coccidium, candida albicans kunye ne-blastomycetes, njl.njl. Iyakubulala i-fugal ekugxininiseni okuphezulu, elichiza elisebenzayo kunyango losulelo lomngundo olunzulu.
Iimpawu eziphambili zeklinikhi ezifana: 1. Unyango lwefungi ezifana ne-cryptococcosis, i-blastomycosis yaseMntla Melika, i-candidiasis esasazwayo, i-coccidiosis kunye ne-histoplasmosis.2. Unyango lwe-mucormycosis olubangelwa ezinye iifungi ezifana ne-Rhizopus, i-colporium, i-endomycetes kunye ne-fecal mold yesele.3. Unyango lwe-sporotrichosis olubangelwa yi-sporotrichosis schenckii.4. Unyango lwe-aspergillosis olubangelwa yi-Aspergillus fumigatus.5. Amalungiselelo asemgangathweni afanelekile kwi-pigmented mycosis.Ikwafanelene nosulelo lomngundo eluswini emva kokutsha, iphecana lokuphefumla iCandida kunye neAspergillus okanye usulelo lwe-cryptococcus, kunye nomsebenzi wezilonda ze-cornea.
Iziphumo ebezingalindelekanga eziqhelekileyo zibandakanya ukusabela ngomkhuhlane, ukugodola, kunye neentloko ezibuhlungu ngokukhawuleza emva kokuba iyeza linikezelwe, kunye nengxaki yezintso.Iimpawu ze-allergic eziquka i-anaphylaxis zingenzeka.Ezinye iziphumo ezibi kakhulu ziquka i-potassium ephantsi yegazi kunye nokuvuvukala kwentliziyo.Kubonakala ngathi kukhuselekile xa ukhulelwe.Kukho i-lipid formulation enomngcipheko omncinci wemiphumo emibi.Kukwiklasi ye-polyene yeyeza kwaye isebenza ngokuyingxenye ngokuphazamisa i-cell membrane yefungus.Kufuneka kusetyenziswe isilumkiso xa iimeko zithe zenzeka, kuba ukusetyenziswa kokhuseleko kufuneka kulandele iingcebiso kubasebenzi bezonyango.
Inkcazo yeBanga loMlomo (kwiMgangatho weNdlu)
| Into | Inkcazo |
| Imbonakalo | Umthubi ukuya kumgubo o-orenji-mthubi, ongenavumba okanye phantse awunavumba. |
| Ukuchongwa | IR, HPLC |
| pH | 4.0-6.0 |
| Ilahleko ekomisweni | ≤5.0% |
| Uthuthu lweSulfated | ≤3.0% |
| Izinto ezinxulumeneyo | ≤0.5% |
| 303nm | Ukungcola A (Amphotericin A) ≤5.0% Ukungcola okungaziwayo komntu ≤1.0% |
| 383nm | Ukungcola B (Amphotericin X1) ≤4.0% Ukungcola okungaziwayo komntu ≤2.0% |
| Ukungcola ngokupheleleyo | ≤15.0% |
| Izinyibilikisi ezishiyekileyo | IMethanol ≤0.3% Iacetone ≤0.5% |
| Isivavanyi | ≥850 amphotericin B iiyunithi/mg into eyomileyo. |
Inkcazo yeBanga loMlomo (kwiMgangatho weNdlu)
| Into | Inkcazo |
| Imbonakalo | Umgubo omthubi ukuya kweorenji awunavumba. |
| Ukuchongwa | IR, HPLC |
| Intsalela ekutshisweni | ≤0.5% |
| Izinto ezinxulumeneyo |
|
| Kwi303nm | I-Amphotericin A ≤2.0% |
| Ukungcola okungaziwayo komntu ≤1.0% | |
| Kwi383nm | I-Amphotericin X1 ≤4.0% |
| Ukungcola okungaziwayo komntu ≤2.0% | |
| Ukungcola okupheleleyo | ≤15.0% |
| Izinyibilikisi ezishiyekileyo | Iacetone ≤0.5% |
| IMethanol ≤0.3% | |
| Umda weMicrobiological | Ubalo lweAerobic microbial ≤1000cfu/g |
| Ukungunda kunye negwele ≤100cfu/g | |
| Escherichia coli Ukungabikho kwi-1g | |
| I-endotoxins yebhaktheriya | <1.0EU/mg |
| Isivavanyi | ≥850 i-amphotericin B iiyunithi / mg, ezibalwe kwisiseko esomileyo |
