Tacrolimus monohydrate 109581-93-3 Antibiotic
Intlawulo:T/T, L/C
Imvelaphi yeMveliso:eTshayina
Indawo yokuthumela ngenqanawa:Beijing/Shanghai/Hangzhou
Umthamo wemveliso:1kg/ngenyanga
Umyalelo(MOQ):1g
Ixesha lokukhokhela:Iintsuku zokusebenza ezi-3
Imeko yokugcina:Igcinwe kwindawo epholileyo, eyomileyo, ubushushu begumbi.
Ipakethe imathiriyeli:ibhotile, ibhotile
Ubungakanani bepakethi:1g/ibhodlela, 5/ibhotile, 10g/ibhotile, 50g/ibhotile, 500g/ibhotile
Ulwazi ngokhuseleko:UN 2811 6.1/PG 3
Intshayelelo
I-Tacrolimus, lichiza le-immunosuppressive.Emva kokufakelwa kwe-allogeneic organ, umngcipheko wokulahlwa kwelungu uphakathi.Ukunciphisa umngcipheko wokulahlwa kwelungu, i-tacrolimus inikwa.Ichiza linokuthi lithengiswe njengeyeza le-topical kunyango lwezifo ze-T-cell-mediated ezifana ne-eczema kunye ne-psoriasis.Ingasetyenziselwa ukuphatha i-syndrome yamehlo eyomileyo kwiikati kunye nezinja.
I-Tacrolimus inqanda i-calcineurin, ebandakanyekayo ekuveliseni i-interleukin-2, i-molecule ekhuthaza ukuphuhliswa kunye nokwanda kweeseli ze-T, njengenxalenye yempendulo yomzimba efundwayo (okanye i-adaptive).
Inkcazo (USP43)
| Into | Inkcazo |
| Imbonakalo | Umgubo omhlophe okanye ophantse umhlophe wekristale |
| Ukuchongwa | IR, HPLC |
| Ukunyibilika | Inyibilika kakhulu kwi-methanol, inyibilika ngokukhululekileyo kwi-N, N dimethylformamide nakwi-alcohol, ngokuthe ngqo ekunyibilikeni emanzini. |
| Intsalela ekutshisweni | ≤0.10 % |
| Ukungcola kwezinto eziphilayo (inkqubo-2) | Ascomycin 19-epimer ≤0.10 % |
| Ascomycin ≤0.50 % | |
| I-Desmethyl tacrolimus ≤0.10 % | |
| Tacrolimus 8-epimer ≤0.15 % | |
| Tacrolimus 8-propyl analog ≤0.15 % | |
| Ukungcola okungaziwayo -I ≤0.10 % | |
| Ukungcola okungaziwayo -II ≤0.10 % | |
| Ukungcola okungaziwayo -III ≤0.10 % | |
| Ubumdaka bubonke ≤1.00 % | |
| Ujikelezo lwamehlo (ngokwesiseko) (10mg/ml kwi-N,Ndimethylformamide) | -110.0 ° ~ -115.0 ° |
| Isiqulatho samanzi (nge-KF) | ≤4.0% |
| Izinyibilikisi ezishiyekileyo (ngu-GC) | I-acetone ≤1000ppm (Endlwini) |
| I-Di-isopropyl ether ≤100ppm (Endlwini) | |
| I-ethyl ether ≤5000ppm | |
| I-Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Uvavanyo lweMicrobial (endlwini) | Ubalo olupheleleyo lwe-aerobic microbial ≤100cfu/gm |
| Iyonke igwele kunye nokubala kokungunda ≤10cfu/gm | |
| Izinto eziphilayo ezichaziweyo (iiPathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) kufuneka zingabikho | |
| Uvavanyo (nge-HPLC) (kwisiseko se-anhydrous kunye ne-solvent free basis) | 98%~102% |
