Iityhubhu zeLebhu

Imveliso

Orlistat 96829-58-2 Antiobesity Diet supplement

Inkcazelo emfutshane:

Izithethantonye:(-)- Tetrahydrolipstatin, Ro-18-0647,

N- Formyl- L-leucine (1S)- 1- [[(2S,3S)- 3- hexyl- 4- oxo- 2- oxetanyl]methyl]dodecyl ester

Inombolo yeCAS:96829-58-2

Umgangatho:USP42

Ifomula yemolekyuli:C29H53NO5

Ubunzima beFomula:495.73


Iinkcukacha zeMveliso

Iithegi zeMveliso

Intlawulo:T/T, L/C
Imvelaphi yeMveliso:eTshayina
Indawo yokuthumela ngenqanawa:Beijing/Shanghai/Hangzhou
Umthamo wemveliso:800kg/ngenyanga
Umyalelo(MOQ):25kg
Ixesha lokukhokhela:Iintsuku zokusebenza ezi-3
Imeko yokugcina:Igcinwe kwindawo epholileyo, eyomileyo, ubushushu begumbi.
Ipakethe imathiriyeli:igubu
Ubungakanani bepakethi:25kg/igubu
Ulwazi ngokhuseleko:Ayizompahla eziyingozi

I-Orlistat

Intshayelelo

I-Orlistat yinto esebenza ixesha elide kwaye inamandla ethile ye-gastrointestinal lipase inhibitor.Imhlophe okanye iphantse ibe ngumgubo omhlophe kwiqondo lobushushu begumbi, enganyibiliki emanzini, inyibilika kwichloroform, kwaye inyibilika ngokulula kwi-ethanol.Ingasebenzi i-enzyme ngokwenza i-covalent bonds kunye neendawo ezisebenzayo ze-serine ze-gastric lipase kunye ne-pancreatic lipase kwisisu kunye namathumbu amancinci.

I-Orlistat luhlobo lweziyobisi ze-lipase inhibitor zokunciphisa umzimba.I-hydrated derivative ye-lipstatin, enokunciphisa ukunyuswa kwamafutha okutya kunye nokunciphisa ubunzima.Le mveliso ine-inhibition enamandla kunye ne-inhibition ye-gastric lipase kunye ne-pancreatic lipase, ayinayo impembelelo kwezinye i-enzymes zokugaya (i-amylase, i-trypsin, i-chymotrypsin) kunye ne-phospholipase, kwaye ayichaphazeli ukuxutywa kwe-carbohydrates, iiprotheni kunye ne-phospholipids.Iyenza isebenze i-enzyme ikakhulu ngokubopha i-covalent kunye neentsalela ze-serine kwiindawo ezisebenzayo ze-gastric lipase kunye ne-pancreatic lipase kwi-gastrointestinal tract, inqanda i-hydrolysis ye-triacylglycerol, inciphisa ukungena kwe-monoglyceride kunye ne-fatty acid yamahhala, kwaye ngaloo ndlela ilawula ubunzima bomzimba.Ichiza alifuntshwa ngumtya wesisu, kwaye ukuvinjwa kwe-lipase kubuyiselwa umva.

Le mveliso nayo inomsebenzi wokulawula i-lipids yegazi.Inokunciphisa i-triglyceride kunye ne-low-density lipoprotein cholesterol kwi-serum yezigulana ezityebileyo kunye nokwandisa umlinganiselo we-high-density lipoprotein ukuya kwi-low-density lipoprotein.

Xa i-orlistat idibene nokutya okuphantsi kweekhalori, ifanelekile kunyango lwexesha elide lwabantu abatyebileyo nabatyebileyo, kubandakanywa nabo baye baphuhlisa izinto ezinobungozi ezinxulumene nokutyeba.Inomsebenzi wokulawula ubunzima bexesha elide njengokulahleka kwesisindo, ukugcinwa kobunzima kunye nokuthintela ukuphindaphinda.Iklinikhi ibonisa ngokucacileyo ukuba umsebenzi wokulawula ubunzima uluncedo kakhulu ekusebenziseni ixesha elide xa inkampani isitya okanye emva kweyure enye yokutya.

I-Orlistat inokunciphisa izinga lokunyanzeliswa kwezinto ezinobungozi ezinxulumene nokutyeba kunye nezinye izifo ezinxulumene nokutyeba, kuquka i-hypercholesterolemia, uhlobo lwe-II yeswekile, ukunyamezela kwe-glucose, i-hyperinsulinemia, i-hypertension, kunye nokunciphisa umxholo wamafutha kwizitho.

Inkcazo (USP42)

Into

Inkcazo

Ukuchongwa

HPLC, IR
Ukujikeleza okuthe ngqo -48.0 ° ~ -51.0 °
Isiqulatho samanzi ≤0.2%
Izinto ezinxulumeneyo I Ikhompawundi enxulumene ne-Orlistat A ≤0.2%
Izinto ezinxulumene II Ikhompawundi enxulumene ne-Orlistat B ≤0.05%
Izinto ezinxulumeneyo III

 

Formylleucine ≤0.2%

Ikhompawundi enxulumene ne-Orlistat C ≤0.05%

I-Orlistat vula i-epimer yeringi ≤0.2%

I-D-Leucine orlistat ≤0.2%

Ukungcola komntu ngamnye okungachazwanga ≤0.1%

Izinto ezinxulumeneyo IV

Ikhompawundi enxulumene ne-Orlistat D ≤0.2%

I-Orlistat vula i-amide yeringi ≤0.1%

Izinto ezinxulumeneyo V

Ikhompawundi enxulumene ne-Orlistat E ≤0.2%

Ubumdaka bubonke (I ukuya ku-V)

≤1.0%

Izinyibilikisi ezishiyekileyo

IMethanol ≤0.3%

I-EtOAc ≤0.5%

n-Heptane ≤0.5%

Intsalela ekutshisweni

≤0.1%

Iintsimbi ezinzima njengePb

≤20ppm

Uvavanyo lwe-HPLC

98.0% ~ 101.5% (kwisiseko se-anhydrous, i-solvent-free basis)


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